Support our Kickstarter

Endocrine Disruptors, Big Pharma, and BHRT

nunorbg.JPG

Hormones are life-giving chemical messengers which are essential to our physical and emotional wellbeing. Progesterone, testosterone, estrogen, pregnenolone, and others are responsible for transporting information throughout the body, ensuring that our organs maintain a healthy synergy. A compromised endocrine system makes it difficult or impossible for the body to function correctly. We are currently facing a crisis in the realm of hormonal health as our exposure to endocrine-disrupting industrial chemicals increases year by year. Our hardworking livers are incapable of processing and filtering out all the plastics, heavy metals, pesticides, and flame retardants which find their way into our bodies on a daily basis. As a result of this increased toxic burden (which is compounded by a sugary, grain-laden Standard American Diet), we are witnessing skyrocketing rates of reproductive cancers, hypothyroidism, heart disease, depression, anxiety, adrenal fatigue, infertility, and a host of other avoidable illnesses. Although the ultimate answer to this problem is the elimination of the offending chemical compounds, there is a short-term solution that the pharmaceutical giants don't want you to know about called Bioidentical Hormone Replacement Therapy, or BHRT.

Bioidentical hormones are manufactured hormones which are molecularly identical to those produced by our own bodies. Unlike their synthetic counterparts, bioidenticals are easily recognized and synthesized by the body and, given a proper dose, can be incredibly powerful yet gentle medicine. The sticking point for Big Pharma is the fact that these compounds are naturally occurring in the human body, which means that they cannot be patented and they therefore offer very little potential for profit.

Many people who have heard of BHRT think of it as something that perimenopausal women turn to in order to deal with unpleasant hot flashes and insomia. As a 25-year-old female who has experienced profound physical and emotional healing with the help of bioidentical progesterone, I know that this medicine is much more than a treatment for the discomfort of menopause. For over five years I visited conventional doctors hoping to find some relief from my persistent nausea, migraines, weight loss, dizziness, fatigue, panic attacks, night sweats, acne, and debilitating PMS. Over and over again the doctors offered me two things -- birth control pills and antidepressants. I knew instinctively that neither of these drugs would make me well and I had no desire to tamper blindly with my internal chemistry. I felt intuitively that something in my body was in a serious state of imbalance and that adding a pharmaceutical cocktail to the mix was not going to fix anything.

I turned to raw foods and lifestyle changes, which brought immediate but incomplete relief. At this point I became certain that I was dealing with some kind of toxicity within my body -- that this illness was the product of a naively unhealthy lifestyle. I attempted for a long time to heal myself with living foods and yoga but I couldn't quite achieve robust health. After I graduated from school and entered the working world I realized that I could no longer continue limping along in a state of quasi-sickness. I was burning out. My reading and research ultimately led me to suspect that my endocrine system had gone haywire, that I needed to both detoxify my body and "reset" my hormonal levels. I couldn't believe that I was doomed to languish forever in this undiagnosed sickly limbo -- I felt certain that vibrant health and happiness were at some level written into my DNA; that I would be able to experience profound healing if I could only support my body and enable it to return to a natural, balanced state.

I googled for a holistic doctor in New York who had experience with bioidenticals, which led me to Dr. John Salerno. In May of 2008 I arrived at my first appointment, anxious, underweight and exhausted. Dr. Salerno ordered a huge number of tests -- the first labwork any doctor had ordered for me in over a decade, despite my drenching night sweats and other puzzling symptoms. At my next appointment, my suspicions were confirmed -- not only were my hormones in a state of imbalance, there weren't even enough of them. My estrogen, pregnenolone, testosterone, and progesterone were totally depleted. It appeared my body had become so overwhelmed that my endocrine system had practically shut down. Dr. Salerno explained that he was seeing more and more young women with these kinds of problems -- that this type of sickness wasn't going to go away as long as we continued to assault our bodies with plastics, heavy metals, and processed foods.

I was immediately placed on a daily regimen which consisted of bioidentical estrogen and progesterone. The transformation was rapid and profound. Within days, the nausea which had plagued me for over five years melted away. My appetite was voracious and I began gaining healthy weight almost immediately. I was no longer jolting awake at 5:00 every morning feeling like I was going to throw up or have a heart attack. Perhaps most importantly, I felt happy -- it was as though I were coming home to myself. My body was no longer a scary, hostile environment, and I watched as the skin on my face became clearer with every passing day.

This experience was so exciting and inspiring to me -- I wanted to know everything about the subject so I could tell people how my life had been healed, all thanks to these humble little hormones. I began reading more and more about BHRT, which inevitably led me to a dramatic tale of corporate corruption. In the midst of my progesterone-induced euphoria I was horrified but not entirely surprised to learn that pharmaceutical giant Wyeth and our own FDA were aggressively seeking a ban on bioidentical hormones. Wyeth's "Frankenstein" version of progesterone, named Premarin because it is derived from pregnant mare's urine, wasn't raking in enough cash. The famous Women's Health Initiative study revealed that this synthetic hormone was linked to an increased incidence of breast cancer, stroke, heart disease, and several other serious illnesses. The results were so disconcerting that the WHI study was halted early. Wyeth was losing informed, concerned customers to safer and gentler bioidentical options, and they weren't happy about it. Wyeth insists that their attempts to get bioidenticals banned stems from a sincere concern for the safety of the women who have been prescribed these "dangerous" and "experimental" medicines -- yet Premarin and Prempro are still on the market (despite a 68% decline in profits between 2002 and 2004).

The Wyeth situation is one small piece of a much larger puzzle, and the body of a hormonally-imbalanced woman is a microcosm of our global situation. We are already seeing infertile and hermaphroditic populations of fish and other wildlife. Some of our little girls are beginning puberty before they've even entered kindergarten. Women are miscarrying and men are becoming feminized. If we continue to lay waste to the delicate balance within our own bodies and across our planet, we will be forfeiting a beautiful experience for ourselves as well as dragging the entire ecosystem down with us.

Today as I write this I am healthy and strong. My stomach is calm and my mind is clear and sharp. I still take bioidentical progesterone on a daily basis. I also follow a high-raw paleolithic diet, and I make sure to get as much sunshine and fresh air as is possible here in New York City. The years I spent in a state of dis-ease were entirely worthwhile as they have afforded me precious insight as well as the certainty that an ancient principle of Traditional Chinese Medicine is true, and that it applies to systems far larger than an individual human organism: A restoration of balance is always possible.

 

Image by robot_zombie_monkey, courtesy of Creative Commons license.

Comments

Bioidentical Hormones

Thank you for sharing this information with us. I wonder what we can do to stop Wyeth and the FDA from banning the natural hormones from use. Are there any groups that you know of working on protecting our health rights in this area? The more people who speak up the better. Find you soul...it's the one thing only you can do.

?

Great information! Thanks Laura!

By the way, I found this great resource online: http://www.health.harvard.edu/newsweek/What-are-bioidentical-hormones.ht...

I'm contacting my doctor as soon as I can. I'm currently on Cenestin, but I'm desperately seeking the least harmful path, especially since my use of exogenous hormones is probably going to be long term.

Yes!

Thank you, Salma. 

Fortunately there ARE a lot of people who have taken a stand on this issue, and we're in better shape now than we were one or two years ago.  P2C2 (Patients and Professionals for Customized Care) always has information available about when things are being voted on, etc. We're kind of in a "holding pattern" right now, having had success protecting our rights to estriol (a type of estrogen) in 2008. 

P2C2 info page

And here's another good overview of the whole situation.

From an OB GYN for what it's worth

I have been prescribing bio-identical HRT for at th elast the last 7 years. I have been listed in the back of Suzanne Somers new book Breathrough as a resource; this is a blessing and a curse and I will tell you why. Many of the women that come to me are frustrated by the system and are looking for help. As an allopathic physician I am caught at times between medical boards and research and the patient who wants to do things that may not be accepted by the medical community at large. One of the main problems with BHRT is that while the estriol and progesterone are FDA approved the individual pharmacies making them are not. Because of this I have to make my patients sign consent forms that state that BHRT is not considered "safer" than any other form of HRT. All medications have side effects. There are BHRT meds that are made by big pharmacy and most physicians will prescribe these. They are called Estrace (estradiol) and Prometrium (progesterone). They are limited in their dosing regimens but they are BHRT and they are more than likely covered by insurance. My question would be why not use these over the compunded hormones? I write many prescriptions for compounded hormones and I have no problem with this as a physician because I measure hormone levels in the blood. I can verify that levles are rising into a normal range. What I find fascinating is that people that are angered becauseof Wueth's perceived language also utilize language that is incediary and accusatory; this is not the way to win the battle. Suzanne Somers, in my opinion is bringing attention but it is not the right kind of attention. We need to be pushing for studies on these drugs because that is what will change the minds of academia. The other side does not have an open mind and I think that you should come at them with an open mind not anger. I can honestly say that medicine or physicians are not witholding medication from patients, but they are frightened of lawsuits and the research that states estrogen cause breast cancer and DVT. Physicians do not have to prescribe a medication if the risks outweight the benefits, we just need to make them understand the benefits are immense and they are on an individual basis. Medicine like double blind studies not just someone saying they feel better, and yet these types of studies on BHRT will never be done for the reasons stated above. I would love a discussion thread on this topic and thank you for the article Shawn A. Tassone, M.D.

Studies

I'm menopausal and just started on bioidenticals five months ago after a number of months of misery. They are making a big difference, although finding the balance is tricky. And I have been really frustrated by the lack of studies that even address bioidenticals. At my request my gyn pointed me to a few retrospective studies in europe that seem to indicate that bioidenticals may create more breast cancer but diminish mortality from it and from other illnesses substantially.I don't have them with me, but can post references to them in a few weeks when I get home. Can anyone else post any other resources? I think Shawn's post is great and it is wonderful to hear a doctor who is asking the right questions and hasn't taken a "side" without adequate info.by the way, Oprah has been doing shows on bioidenticals -- so there will now be a ton of publicity for them, which may make the FDA go after them again -- but also is likely eventuallly to lead to decent studies. I just hope they happen soon!Katarina

Who will fund and conduct the studies?

Great comments, guys! I agree that we need studies, but WHO is going to fund and conduct them? Also, what about pharmaceutical fraud, which is a very real issue (and a huge concern of mine in this specific context)? http://tinyurl.com/cb9pwr

Yams and Maca...

That would be my recommendation just on description of condition, not common sweet potato, but real yams,organic soy products also, stevia too if you are not planning a pregnancy,reduce sugar intake and increase probiotics like kim chi...also lots of parsley to clear toxins.

Soy is estrogenic and CAN make things worse, not better!

For some people (myself included) soy can exacerbate hormonal problems. I can't tolerate soy at all. Soy and yams are estrogenic and for a lot of women the problem is estrogen dominance and progesterone deficiency, in which case introducing more estrogens into the body will make the problem worse. AVOIDING these foods can help, as can increasing your intake of broccoli and other cruciferous vegetables which contain indole-3-carbinol and DIM and other compounds which can help to flush excess estrogen out of the body.

I agree that if the imbalance is severe...

soy should be avoided until the imbalance is addressed, but like fats, there is good and bad hormones and each individual is different and everyone should eat more cruciferous vegetables, Maca and stevia can be stabilizing and if heavy metals are present, these can reek all kinds of havoc on endocrine function and parsley is the best defence. Thank you for alerting those  who may be estrogen sensitive.

The Yam Scam

I try to be unibiased when it comes to health care but I do become involved when there seems to be a myth circulating about that is ripping off the health care consumer. Uusually, in these cases, patients tend not to beleive what I am telling them anyway, but here goes. Wild yam is indeed what compounding pharmacies use to make bioidentical hormones. Scam artists hav come into the picture and sell this wild yam cream over the counter and tell you it is progesterone. The first thing to know is that the chemical in wild yams is called dioscorea and we as humans can not use this comopund in our bodies; we do not have the enzymes available to break it down. In the lab they can add enzymes to turn this into progesterone, but we as humans do not have the ability and to us dioscorea is a worthless compound. If you take wild yam then you pee wild yam and you are out $40. The second thing is that there are some companies that tout actual progesterone cream with "real" progesterone". Again, beware the hype because progesterone is a prescription medication. Something becomes a prescripion when it is shown that it causes a chemical change in human tissue. Thus if something is sold over the counter, without FDA approval, it has not been deemed as prescription level and thus has no effect on human tissues. This means that the progesterone cream you buy at Whole Foods does not do anything or it would be considered a prescripion....do you follow me? The other things that I have noted in this thread is the usage of statements without facts or references. This may be an editorial piece rather than a study but it would be better for all of us to back up things with evidence. Sometimes the evidence may be that you feel better, but your arguments fall on deaf ears at times when we use phrases like "Frankenstein" hormones "FDA the cesspit....." when you are trying to be pursuasive it is good to be unbiased and convinvce the other party by stating their side of the sotry and then dismantling it with the scaffolding they beleive in. Use science to defeat the scientist. Rhetoric does not win over the scientist and this fight will be lost because of emotions. Shawn A. Tassone, M.D.

What do you suggest?

Hi Shawn -- When I used the term "Frankenstein hormones" I was referring to the alteration of the molecular structure of the hormones in order to make them eligible for patent. I am writing from the perspective of a patient -- someone who has NOT been through medical school. What I have learned, I have learned through my own experience. I'm not attempting to "defeat" the scientist here -- what I'm more interested in is raising awareness and alerting people to the fact that there's something very wrong within this system. Since you ARE a doctor, what do you suggest? What science would YOU use to "defeat the scientist"? I felt so sick for such a long time, and mainstream medicine literally failed me. I see countless other people who are going through similar ordeals, and my intention is to let those people know that there ARE other options -- you CAN feel better, you CAN be healthy again. This is what I care about and this is what I KNOW. Other than telling me that I'm not being scientific enough, what are you offering in this discussion? I'm not a scientist -- I'm a 25-year-old who had to take her health into her own hands because the system is broken.

Not Sure

Unfortunately, you seem offended and that was not my intention. I was not suggesting that anyone was right or wrong, and I firmly believe there are other options. In my opinion this is not a battle of the physician versus the patient or vice versa, it is a matter of educating both sides. We should try to educate the medical side with evidence based studies and the public should trust that until studies are done, aminstream medicine will have to wait. It is unfortunately the way the system operates, right or wrong. Books like Suzanne Somers "Breakthrough" do more harm that good sometimes, because they champion unknown based purely on anecdotes. If you are the 1 person it helps then then numbers really don't matter because you feel better, but there are many many others out there that by wild yam cream and spend a bunch of money on supplements that have nothing in them. I guess I was looking at your original piece as a factual article or report and not as a bigraphical sketch. The health care system is broken, I agree, but it is something that can be fixed, and my point is that awareness can be brought about in an educational manner. I hope the physicians that you saw in your quest did not intentionally harm you and maybe it was just their own ignorance of other options. They may be great doctors, just not knowledgeable about BHRT. Sorry if I have offended you, obviously, this kind of debate has many angles and maybe everyone has a piece of the truth in their argument. I was just giving my piece. Shawn A. Tassone, M.D.

spread the word

Women seem particularly more susceptible to environmental toxins. We need to be the weather vein for this one. Help spread the word as much as we can. I have spent many years of my life very sick from environmental toxins, garbage food, intolerance to over processed foods. It has been a long haul for me to get to the wellness that I have achieved atm. It's very hard to convey to younger women the dangers of the cumulative effect of many of these hazards and that they should take preventative measures. Hopefully we can come to see that what goes in the stream 100 miles up river effects us 100 miles down river.

So until we have the studies, what are we to do?

Shawn,

What I hear you saying repeatedly is that we "the people" need hard evidence in order to convince the medical establishment that a new approach is needed. But if we need doctors, scientists, and funding in order to conduct those studies and PRODUCE that evidence, we're kind of up a creek, aren't we? How are we to attain those resources when they are, for the most part, controlled by the people whom we are trying to convince?

As far as the wild yam cream is concerned, I am not advocating the use of it or any of the other hormonal "fixes" available at Whole Foods, etc (though I maintain that a sound diet is a critical aspect of hormonal health). I am strictly speaking about prescription hormones from a compounding pharmacy.

I personally feel that anecdotal evidence IS worth something. I am deeply thankful for Suzanne Somers' work, and for the personal stories shared by countless other women who had already been through what I was going through. Those stories motivated me, inspired me, and gave me hope -- and I know that I am not alone in that. Yes, the hard science is important, but so is open dialogue and the sharing of personal experience.

And bannana -- I totally agree, women seem to be the "canaries in the coal mine" when it comes to this type of illness.

The Hard Facts

I think that you get the research going by doing what you are doing and telling state and national congresspeople that this is something they need to support. Our local congresswoman was essential to defeating the Estriol ban by the FDA. You are absolutely correct that anecdotal evidence is worth something....to you. If we can get all of the "yous" and put that data out there, then that will make the medical community turn its ear. I don't think it is bioidentical HRT that is the problem I think the problem the medical establishment has is with the compounding pharmacies. As I stated you can prescibe ESTRACE and PROMETRIUM and these are bioidentical, but they are made by a pharmaceutical company, and they can be regulated by the FDA. Keep on talking. Just by use going back and forth your article has been elevated to one of the more popular ones on this website.....so your article and our discussion hopefully are being noticed Shawn A. Tassone, M.D.

at least Maca still shows potential...

and wild yams taste good and have complex carbs so if not useful hormonally at least they are nutritious, I get them cheap from Super H, they make nice pie, mix them w/common sweet potato and add egg and milk if you aren't pure vegan and do ovo/lacto :-) I'm still working on getting brown sugar flavor by caramelizing the sweet potatoes. BTW, guys love the smell of cinnamon in sweet potato pie ;-)

Endocrine imbalance

Hi Laura, Thanks for sharing your experience. I'm curious what tests your holistic doctor gave you. I'm dealing with figuring out some thyroid issues & would like to encourage my doctor to run full tests as I'd like to figure it all out sooner rather than later & have full info to work with rather than in piecemeal. Greatly appreciated!

more bad news!

I worked in a lab last year studying the effects of endocrine disrupting chemicals (EDC's) on fat cell differentiation and insulin resistance. The paper is not published yet, and it probably will not be for a while - there is still a lot of work to do. I will say that the findings I saw during my time there convinced me that EDC's have the potential to seriously mess with how fat we get (particularly children) and may even contribute to diabetes. Add that to your list of symptoms. Another aspect of the study that has yet to be tested is the hypothesis that EDC's are ultimately trapped in our fat cells because they are typically not water soluble and have no other convenient deposit to go to in the body. If this is correct, it may also be the case that if you shed some weight, the overall concentration of EDC's in your body may actually go up, since their solvent decreases and there is nowhere for the EDC's to go. Of course, you should take this all with a grain of salt. The majority of experiments I am drawing these conclusions from were done in vitro using a mouse cell line. In the body these compounds may behave differently.

Hi there

Coco, sorry for the delayed response -- I've been on a long, self-imposed internet break! Regarding the tests, the most important ones were: total estrogens, progesterone, testosterone, sex hormone binding globulin, pregnenolone, vit D, kidney function, liver function, CBC, full thyroid panel. There was more, but those were the ones we paid the most attention to.
moz, thanks for your comment, that is really fascinating info and does not surprise me at all. What you said about weight loss makes PERFECT sense to me too because (more anecdotal evidence here) my hormonal issues got REALLY bad when I lost about 15 lbs due to stress. At that point I only weighed about 100 lbs, and that was when I was really at my sickest.
I FULLY believe that the hormonal stuff is totally tied into the epidemic of obesity and diabetes in our society.